Primary Objectives:
1. To assess the rate of switches of PrEP regimen by PrEP users (event-driven to daily and daily to event-driven), stop (defined as no PrEP use for 3 months or more) and re-start moments of PrEP use, and its determinants
2. To assess the HIV incidence rate among participants who use event-driven PrEP over the first 4 years of use
Secondary Objectives:
1. To assess changes in sexual behavior and compare these between daily and event-driven PrEP users over the first 4 years of use
2. To assess STI, including HCV, incidence and compare these between daily and event-driven PrEP users over the first 4 years of use
3. To assess the adherence to PrEP medication and compare these between daily and event-driven PrEP users over the first 4 years of use
4. To assess tenofovir disoproxil diphosphate levels in dried blood spots at seroconversion, and resistance patterns of breakthrough HIV infections among PrEP users
Looptijd: 1 juni 2018 - 1 december 2020