The overall aim of the proposed project is to establish a longitudinal cohort of adult patients who are infected with SARS-CoV-2, at different levels of disease severity, ranging from mild illness to severe requiring hospitalization and intensive care. These patients will be followed in a study for one year after initial diagnosis of infection.
This cohort will be used (1) to identify socio-demographic, clinical, virological and/ host factors predictive of disease progression, (2) to Investigate the induction of lasting protective SARS-CoV-2-specific antibody and SARS-CoV-2-specific T cell responses in relation to disease severity, clinical recovery or re-infection over time and (3) to gather insight into the clinical and socio-psychological sequelae of COVID-19. In addition, (4) a data- and biobank will be established for future in-depth pathophysiological, immunological, host-genetic and further clinical and epidemiologic studies.
Looptijd: 10-4-2020 - 31-12-2023