Research within this theme aims to identify genetic risk factors and cellular pathomechanisms underlying cardiac disorders associated with increased risk of sudden cardiac death. The focus is placed on genotype-phenotype studies and arrhythmia mechanisms in different cardiac pathologies, among which hypertrophic cardiomyopathy and arrhythmogenic cardiomyopathy, primary arrhythmogenic syndromes (Long QT syndrome, cardiac conduction disease and Brugada syndrome) and myocardial infarction/ischemia. The research includes discovery of genetic factors which cause or modify cardiac disease, investigation of underlying (pro)arrhythmic mechanisms, and identification of novel targets for diagnosis, risk stratification and therapy, including the interaction between structure and function.
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Source and more ongoing research lines within heart failure & arrhythmias: Amsterdamresearch.org
